CJC-1295 (no DAC)

CJC-1295 without DAC, also known as Modified GRF (1-29) or Mod GRF 1-29, is a truncated and modified form of GHRH with a shorter half-life of approximately 30 minutes compared to the DAC variant. It promotes acute, pulsatile growth hormone release that closely mimics the body's natural GH secretion dynamics, making it ideal for research into physiological GH patterns. The peptide contains four amino acid substitutions at positions 2, 8, 15, and 27 (Ala→D-Ala, Gly→Ala, Gly→Ala, Met→Leu) to improve metabolic stability and receptor binding affinity while preventing DPP-IV enzymatic cleavage. Research applications include investigation of acute GH pulse dynamics, synergistic effects when combined with GHRP-class peptides, and studies on the hypothalamic-pituitary somatotropic axis. Its shorter duration of action allows researchers to study GH pulse frequency, amplitude modulation, and the effects of various dosing intervals on IGF-1 response curves.