{"id":195,"date":"2026-07-08T02:08:44","date_gmt":"2026-07-08T00:08:44","guid":{"rendered":"https:\/\/synerium.info\/product\/tesofensine-500mcg\/"},"modified":"2026-07-22T22:24:16","modified_gmt":"2026-07-22T20:24:16","slug":"tesofensine-500mcg","status":"publish","type":"product","link":"https:\/\/synerium.info\/hr\/product\/tesofensine-500mcg\/","title":{"rendered":"Tesofensine"},"content":{"rendered":"

Tesofensine is a novel serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI) originally developed by NeuroSearch for neurological conditions (Alzheimer’s and Parkinson’s disease) before its potent weight-reducing effects were identified during clinical trials. It inhibits the presynaptic reuptake of all three monoamine neurotransmitters \u2014 serotonin (5-HT), norepinephrine (NE), and dopamine (DA) \u2014 with relative potencies of approximately 1:2:3 (DA>NE>5-HT). This triple reuptake inhibition produces synergistic effects on appetite suppression through hypothalamic satiety center activation, thermogenesis enhancement through sympathetic nervous system stimulation, reward circuit modulation that reduces food-seeking behavior, and potential improvement in mood and motivation. Phase II clinical trials demonstrated average weight reductions of 10-13% over 24 weeks \u2014 among the largest reductions observed for any pharmacological intervention at the time. Research applications include studies on monoamine signaling in appetite regulation, comparative pharmacology of selective versus non-selective reuptake inhibitors, CNS mechanisms of food intake control, and the relationship between dopaminergic reward signaling and eating behavior.<\/p>\n","protected":false},"excerpt":{"rendered":"

Tesofensine is a novel serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI) originally developed by NeuroSearch for neurological conditions (Alzheimer’s and Parkinson’s disease) before its potent weight-reducing effects were identified during clinical trials. It inhibits the presynaptic reuptake of all three monoamine neurotransmitters \u2014 serotonin (5-HT), norepinephrine (NE), and dopamine (DA) \u2014 with relative potencies of approximately 1:2:3 (DA>NE>5-HT). […]<\/p>\n","protected":false},"featured_media":194,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[25],"product_tag":[],"class_list":["post-195","product","type-product","status-publish","has-post-thumbnail","product_cat-tablets","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nTesofensine - Synerium<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/synerium.info\/hr\/product\/tesofensine-500mcg\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tesofensine - Synerium\" \/>\n<meta property=\"og:description\" content=\"Tesofensine is a novel serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI) originally developed by NeuroSearch for neurological conditions (Alzheimer’s and Parkinson’s disease) before its potent weight-reducing effects were identified during clinical trials. It inhibits the presynaptic reuptake of all three monoamine neurotransmitters \u2014 serotonin (5-HT), norepinephrine (NE), and dopamine (DA) \u2014 with relative potencies of approximately 1:2:3 (DA>NE>5-HT). 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