GHK-Cu (Copper Peptide GHK-Cu, Glycyl-L-Histidyl-L-Lysine:Copper(II)) is a naturally occurring tripeptide-copper(II) complex first identified in human plasma in 1973 by Dr. Loren Pickart. Its plasma concentration decreases significantly with age \u2014 from approximately 200 ng\/mL at age 20 to 80 ng\/mL by age 60 \u2014 paralleling the decline in tissue regenerative capacity. GHK-Cu is one of the most extensively studied regenerative compounds, with research demonstrating its involvement in over 4,000 gene expression changes, many of which reset gene expression patterns toward a younger, healthier state. Documented research effects include stimulation of collagen I, III, and V synthesis, upregulation of decorin (a collagen-organizing proteoglycan), increased production of metalloproteinases for ECM remodeling, enhancement of superoxide dismutase (SOD) and other antioxidant enzymes, promotion of angiogenesis and nerve outgrowth, anti-inflammatory activity through IL-6 and TNF-\u03b1 suppression, stimulation of glycosaminoglycan synthesis in fibroblasts, attraction of immune cells and mesenchymal stem cells to wound sites, and hair follicle growth stimulation through Wnt\/\u03b2-catenin pathway activation. This 1500 mg format supports large-scale in-vitro studies, formulation development, and multi-condition experimental designs.<\/p>\n","protected":false},"excerpt":{"rendered":"
GHK-Cu (Copper Peptide GHK-Cu, Glycyl-L-Histidyl-L-Lysine:Copper(II)) is a naturally occurring tripeptide-copper(II) complex first identified in human plasma in 1973 by Dr. Loren Pickart. Its plasma concentration decreases significantly with age \u2014 from approximately 200 ng\/mL at age 20 to 80 ng\/mL by age 60 \u2014 paralleling the decline in tissue regenerative capacity. GHK-Cu is one of […]<\/p>\n","protected":false},"featured_media":124,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[21],"product_tag":[],"class_list":["post-125","product","type-product","status-publish","has-post-thumbnail","product_cat-cosmetic","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\n