{"id":110,"date":"2026-07-08T02:08:37","date_gmt":"2026-07-08T00:08:37","guid":{"rendered":"https:\/\/synerium.info\/product\/nad-plus-500mg\/"},"modified":"2026-07-09T00:26:59","modified_gmt":"2026-07-08T22:26:59","slug":"nad-plus-500mg","status":"publish","type":"product","link":"https:\/\/synerium.info\/es\/product\/nad-plus-500mg\/","title":{"rendered":"NAD+"},"content":{"rendered":"<p>NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in all living cells, serving as the central mediator of cellular energy metabolism and a substrate for several families of enzymes critical to health and longevity. As an electron carrier, NAD+ cycles between oxidized (NAD+) and reduced (NADH) forms to drive ATP production through glycolysis, the TCA cycle, and oxidative phosphorylation. Beyond energy metabolism, NAD+ serves as an essential substrate for three key enzyme families: sirtuins (SIRT1-7) \u2014 NAD+-dependent deacetylases that regulate gene expression, DNA repair, circadian rhythms, and mitochondrial biogenesis; PARPs (poly-ADP-ribose polymerases) \u2014 DNA repair enzymes that consume NAD+ during the damage response; and CD38\/CD157 \u2014 ectoenzymes involved in calcium signaling and immune function. NAD+ levels decline by approximately 50% between ages 40 and 60 in human tissues, and this decline is increasingly recognized as a driver of age-related metabolic dysfunction, neurodegeneration, and cardiovascular disease. This high-purity research compound is used in studies on mitochondrial function restoration, sirtuin activation kinetics, PARP-mediated DNA repair capacity, circadian clock gene regulation, and cellular senescence reversal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in all living cells, serving as the central mediator of cellular energy metabolism and a substrate for several families of enzymes critical to health and longevity. As an electron carrier, NAD+ cycles between oxidized (NAD+) and reduced (NADH) forms to drive ATP production through glycolysis, the [&hellip;]<\/p>\n","protected":false},"featured_media":109,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[20],"product_tag":[],"class_list":["post-110","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NAD+ - Synerium<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/synerium.info\/es\/product\/nad-plus-500mg\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NAD+ - Synerium\" \/>\n<meta property=\"og:description\" content=\"NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in all living cells, serving as the central mediator of cellular energy metabolism and a substrate for several families of enzymes critical to health and longevity. 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