SLU-PP-332 is a synthetic agonist of estrogen-related receptors alpha and gamma (ERR\u03b1\/\u03b3), developed at Washington University in St. Louis as a first-in-class exercise mimetic compound. ERR transcription factors are master regulators of the exercise-adapted gene expression program, controlling genes involved in mitochondrial biogenesis (PGC-1\u03b1, NRF1, TFAM), fatty acid oxidation (CPT1, MCAD, VLCAD), oxidative phosphorylation (cytochrome c, ATP synthase subunits), angiogenesis in muscle tissue, and fiber-type switching toward oxidative (slow-twitch) phenotype. Research has demonstrated that SLU-PP-332 activates many of the same transcriptional programs as endurance exercise training, including increased running endurance in sedentary mice and resistance to diet-induced obesity. The 750 mcg tablet format is suitable for dose-ranging studies and initial dose-response characterization in exercise physiology, metabolic disease, and muscle biology research.<\/p>\n","protected":false},"excerpt":{"rendered":"
SLU-PP-332 is a synthetic agonist of estrogen-related receptors alpha and gamma (ERR\u03b1\/\u03b3), developed at Washington University in St. Louis as a first-in-class exercise mimetic compound. ERR transcription factors are master regulators of the exercise-adapted gene expression program, controlling genes involved in mitochondrial biogenesis (PGC-1\u03b1, NRF1, TFAM), fatty acid oxidation (CPT1, MCAD, VLCAD), oxidative phosphorylation (cytochrome […]<\/p>\n","protected":false},"featured_media":189,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[25],"product_tag":[],"class_list":["post-190","product","type-product","status-publish","has-post-thumbnail","product_cat-tablets","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\n