5-Amino-1MQ (5-Amino-1-methylquinolinium) is a potent small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme highly expressed in white adipose tissue that plays a critical role in cellular energy metabolism, one-carbon metabolism, and epigenetic regulation. NNMT catalyzes the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), consuming S-adenosyl methionine (SAM) in the process. NNMT overexpression is associated with obesity, type 2 diabetes, and cancer. Research demonstrates that NNMT inhibition by 5-Amino-1MQ produces multiple beneficial metabolic effects: increased intracellular NAD+ levels by redirecting nicotinamide toward NAD+ salvage, enhanced SIRT1 activity through elevated NAD+, reduced adipocyte lipid accumulation and triglyceride content, increased cellular energy expenditure and oxygen consumption, reduced body fat mass without affecting lean tissue or food intake in animal models, and modulation of SAM:SAH ratios affecting global methylation patterns. This oral tablet format provides 60 doses at 50 mg per tablet for convenience in chronic dosing research protocols.<\/p>\n","protected":false},"excerpt":{"rendered":"
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a potent small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme highly expressed in white adipose tissue that plays a critical role in cellular energy metabolism, one-carbon metabolism, and epigenetic regulation. NNMT catalyzes the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), consuming S-adenosyl methionine (SAM) in the process. NNMT overexpression is associated […]<\/p>\n","protected":false},"featured_media":178,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[25],"product_tag":[],"class_list":["post-179","product","type-product","status-publish","has-post-thumbnail","product_cat-tablets","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\n